To create parameterized queries using SingleStore's Table-Valued Functions and execute them via the Data API, first set up a SingleStore database and tables, then create a Table-Valued Function (TVF) that accepts input parameters and executes a single SELECT statement. The TVF can be accessed via the SingleStore Data API, allowing for automation of data ingestion and query execution through scripts or ETL tools. This approach enables efficient management and execution of complex queries within the SingleStore ecosystem, providing a powerful solution for data management and analysis.