Neo4j Enterprise Edition offers advanced features for administering native users, including managing user roles, suspending and activating users, changing passwords, and synchronizing changes across a cluster. Built-in System Procedures provide flexibility for scripting individual actions, while providing a range of views to examine the details of users and roles. Native users can view their assigned roles and change their passwords, but changes must be manually synchronized across a cluster or through automated processes. The system ensures that only authenticated users and applications can access the graph database.