The guide uses the open-source framework Pipecat to set up a real-time AI voice agent, allowing users to interact with it using an Android app. The server and client interact using the RTVI protocol, ensuring low latency and stability over mobile data connections. To get started, users can clone the Pipecat repository, set up a virtual Python environment, and install necessary dependencies. They need API keys for Gemini (LLM) and Daily (WebRTC transport). After setting up the server, users can make it accessible to their Android device using ADB reverse, ngrok, or configuring local firewall settings. The Android client app is created with the Pipecat client and Accompanist library, allowing users to connect to the RTVI backend over cleartext HTTP. Users need to request internet and audio permissions in their AndroidManifest.xml file. Once the app is run, users can have a two-way voice conversation with the bot. The guide also provides next steps for customizing the chatbot by modifying its code.