Memorial Sloan Kettering Cancer Center's cBioPortal, a leading platform for precision oncology, has struggled with performance issues due to its reliance on MySQL and old data infrastructure. The team has since turned to ClickHouse, an analytical database that can process massive datasets at high speed, to improve the platform's scalability and speed. With ClickHouse, researchers can analyze complex cancer data faster and accelerate breakthroughs in cancer treatment and personalized care. The implementation of ClickHouse has proven its potential to transform cBioPortal, enabling near-real-time hypothesis testing and accelerating the pace of discovery.