To improve the organization and cleanliness of your Excel spreadsheet, you can delete blank rows individually or in bulk using a combination of mouse clicks and formulas. To remove individual blank rows, select the row(s) by clicking on their numbers, dragging to nearby rows if necessary, and right-clicking to delete them. For larger datasets, use the COUNTA formula to identify completely blank rows, add this formula as a new column, filter the spreadsheet to find these rows, and then delete them using the `Delete Rows` option. Additionally, you can automate your Excel spreadsheets by connecting it to Zapier, which allows for automatic data updates and actions.