Ruthlessly prioritizing tasks is a powerful way to ensure completion of to-do lists, allowing individuals to focus on the most important tasks first. Consolidating all tasks into a single source, such as a digital tool or spreadsheet, enables efficient analysis and prioritization. Techniques like relative prioritization, focusing on Most Important Tasks (MITs), and identifying key 20% work provide effective methods for managing task lists. By applying these strategies, individuals can optimize their productivity and achieve a better work-life balance.