PowerToys Run` is a feature in `Microsoft PowerToys`, a collection of tools that enhances Windows, allowing users to quickly access and launch applications, files, and folders using a search bar. The tool provides features such as quick math calculations, system commands like shutdown or restart, and integration with OneNote for searching notebooks. While it may not match the full capabilities of Spotlight on Macs, `PowerToys Run` offers faster access to computer content than any Windows tool, making it an essential addition to the Microsoft PowerToys collection.