**Choosing the right domain extension is crucial for businesses and individuals alike as it affects trustworthiness and memorability of a website's URL. The most trustworthy and memorable option is `.com`, but its availability can be limited due to high demand. Alternative options include `.co`, which shares similarities with `.com` but may lead to confusion, and `.org`, which offers a distinct advantage in differentiating from `.com` counterparts. Country-code TLDs (ccTLDs) like `.us` or `.uk` can provide a safe middle ground if the high-priority options are unavailable, but they may come across as patriotic, which could work for or against a brand. Ultimately, the best domain extension depends on individual circumstances and priorities.