You can set up a Gmail out of office message on both the web and mobile versions of the app, providing a clear subject line and brief message to inform recipients of your unavailability. When setting up an out of office reply, it's essential to consider tips such as keeping the message concise, not including personal details like email addresses, and telling recipients when you'll be back in the office. The feature can be turned off at any time, and saved settings will sync across devices. Additionally, Gmail offers automation options through Zapier integrations, allowing users to streamline their inbox and connect with other apps for enhanced productivity.