gRPC is better suited for performance-critical systems that require high-speed, low-latency communication between services. Its binary serialization via Protocol Buffers and HTTP/2 support make it ideal for real-time analytics, video streaming, or financial services. GraphQL, on the other hand, excels in client-driven applications with intricate requirements, providing a flexible querying approach and streamlined data delivery. The choice between gRPC and GraphQL ultimately depends on the specific needs of your project, requiring careful consideration of factors such as performance, scalability, and team expertise. Both frameworks can be combined in hybrid architectures that leverage their strengths to create a balanced solution.