Vector search engines are becoming essential components in AI applications, transforming complex data into numerical vectors that can be efficiently searched against raw data. However, working with image or video data and incorporating vector search into workflows can present challenges such as implementing cross-modal retrieval and handling traditional search filters. FiftyOne is an open source computer vision interface for vector search, allowing users to use their preferred vector search engine in a single line of code. With native integrations with Qdrant, Pinecone, LanceDB, and Milvus, FiftyOne simplifies semantic searches using natural language queries and supports object detection patches.