You can implement sensitive PII information detection in email sends using Azure AI, .NET, and Twilio SendGrid. This involves setting up an Azure Text Analytics resource to analyze text data, installing required NuGet packages for the .NET application, creating configuration keys for the application, and writing code to detect and redact sensitive data before sending the email. The application flow is triggered when an email send is activated, passing the email data to a PII detection service to identify and mask any sensitive information, which is then sanitized and sent via Twilio SendGrid. By implementing this solution, you can significantly reduce the risk of accidentally leaking sensitive information, maintaining compliance and user trust.