This article explores how Twilio AI Assistants integrates with different communication channels such as voice and messaging channels like SMS, WhatsApp, and Twilio Flex Webchat. The integration patterns for these channels are discussed along with a step-by-step guide to configure the integrations using an open-source quickstart middleware. The middleware provides features like multilingual support, secure connections, and handover to live agents on Twilio Flex. The article also covers how to deploy the middleware using Twilio Functions and sets up the necessary prerequisites for integration.