The new Twilio Runtime API and Serverless Toolkit offer a more streamlined way to create, develop, and deploy Twilio functions. With the CLI's serverless plugin, developers can now easily deploy their functions to production and manage their codebase using a single command. The toolkit also provides pre-defined templates for creating new functions, which reduces repetitive tasks and makes development more convenient. Additionally, the API supports environments, allowing developers to test and deploy changes in isolation without affecting their production setup. This feature is crucial for large projects with multiple developers working on the same codebase. Furthermore, the automation of Twilio setups using a single command has made it possible to buy numbers, create sync services, and connect communication channels via functions. The new API and Serverless Toolkit are expected to revolutionize the way developers work with Twilio.