A telemedicine waiting room with Twilio Video is built using Node.js and Express to create a HIPAA-compliant solution for healthcare providers and patients. The application allows users to join a video call, interact with a virtual waiting room, and display their local audio and video streams on the page. The system also includes event listeners to handle participant connections and disconnections, as well as toggle buttons for joining and leaving the room. The patient experience is designed to show a soothing campfire video while they wait, which can be replaced with other content in the future. The application demonstrates how Twilio Video can be used to create innovative telemedicine solutions, including features such as pre-appointment reminders and recording of audio from visits.