Secure video conferencing requires ensuring only registered users can access the conference. One-time passcode authentication using Twilio Verify can help achieve this. The tutorial adds Twilio Verify to a Twilio Video application using Python and Flask, requiring a free or paid Twilio account, Python 3.6 or newer, and a web browser compatible with the Twilio Programmable Video JavaScript SDK. It sets up an Access Control List (ACL) to authenticate participants and sends an SMS with a one-time passcode for verification. The application then checks the code and returns an AccessToken JWT if verified correctly, allowing only known participants to join the video conference.