You can receive a phone call in Python using Django and Twilio by creating a web application that listens for incoming calls, processes the call information, and responds accordingly. To start, create a new Django project and virtual environment, install the required packages, including Django, Twilio, and Pyngrok. Configure the Django project to use a Twilio phone number as an endpoint for incoming calls. Use the Twilio Python Helper library to work with voice calls and generate TwiML responses. The TwiML language allows you to instruct Twilio on how to handle the call, such as playing a message or connecting to another call. Once configured, test the application by calling the Twilio phone number and verifying that it responds correctly.