You can build a one-time passcode protected conference line using Twilio Verify and Python, offering additional security by ensuring users have access to the phone and number they claim to own. By sending an OTP to the user's number or email, you can have confidence that the person joining your call is who they say they are. The code in this post secures a conference line in two ways: checking known participants and preventing phone number spoofing with OTPs. To set up protected conference calls in Python, you need a Twilio account, a Twilio phone number, the Twilio Python helper library, and a Verify Service. You create a settings file to store your credentials, define known participants, and start your Flask application. The code then asks the caller to input a 6-digit code and connects them to a conference call without verifying those digits yet. To protect the conference line, you add functions to start verification and check verification, which use the Verify API to send OTPs and verify codes.