To avoid the end-of-life status of Node.js v10, developers using Twilio Functions must update their projects to use Node.js 12. This involves specifying the correct runtime flag when deploying the project, testing it locally with Node.js 12, and verifying its functionality in the production environment. After April 30, the --runtime=node10 flag will no longer be valid, and future deployments should use Node.js 12 explicitly unless necessary.