You can make a phone call using Twilio Programmable Voice and Python. To start, you need to set up your environment by creating a new Python project and installing the necessary dependencies. You also need to define your Twilio credentials as environment variables. Next, you buy a Twilio phone number and create a TwiML bin that contains instructions on how to handle the phone call. Finally, you use the Twilio Python Helper library to make a phone call in Python by creating a new instance of the Client class and calling the `calls.create` method with your Twilio phone number, target phone number, and URL to the TwiML bin.