As countries race to vaccinate residents for COVID-19, communications will play a critical role in ensuring effective and equitable vaccine dissemination. Public health stakeholders need to provide clear, accurate information about vaccination effectiveness and availability through various communication channels such as email, SMS, voice, and WhatsApp to reach specific population segments across different media and languages. Digital communications can promote vaccine effectiveness by helping patients ensure they receive their second dose. To address the challenges of rolling out vaccination programs, Twilio is providing frameworks for building communications solutions that include public information and engagement, enrollment and registration, appointment coordination, monitoring vaccine effectiveness, and distribution logistics.