You can send an SMS with Node.js using Twilio's API. To start, you need to have a free or paid Twilio account and install the required packages, including the Twilio Node.js Helper Library and dotenv. You also need to set up your project by creating two new files: index.js and .env. In the .env file, you add your Twilio account credentials as environment variables. Next, you buy a Twilio phone number and use it to send an SMS to your personal phone number. The code is then written in index.js using the Twilio library to create a new instance of the client and send an SMS with the message "Ahoy, friend!". After running the code, you see the message SID logged to the terminal, and soon receive a ping on your personal phone with the SMS.