A Python script using Flask, Twilio SMS, and Trello APIs creates an application that responds to incoming text messages with a randomly selected "To-Do" item from the user's Trello board. The script starts by setting up the environment, including installing necessary packages, creating a virtual environment, and authenticating with the Trello API. It then defines a function `get_todo_item()` that extracts To-Do items from the user's Trello board and returns one randomly chosen item. The Flask server is set up to respond to incoming text messages with the selected To-Do item. The application can be extended by integrating additional logic, such as calculating the length of neglected tasks.