This guide helps developers integrate Twilio Programmable Voice with a Django application to create an Interactive Voice Response (IVR) system for managing pizza orders over the phone. The IVR uses touch-tone keypad selections to guide users through menu options, storing menu choices and responses in an SQL database managed by Django's ORM. By following this tutorial, developers can build a fully functional IVR system with Twilio Programmable Voice, allowing customers to place orders and receive confirmation messages via voice calls.