Laravel and Pusher are integrated to create a real-time Twitter stream. The application sets up a new Laravel project, adds a frontend with a custom CSS and JS file, and creates a console command to fetch tweets from Twitter using the laravel-twitter-streaming-api package. A Pusher channel is created and the client-side is updated to subscribe to the "tweets" event. The server broadcasts the tweet data to the client using the `broadcast()` function, which is implemented in the `Tweets` event class. The console command is used to fetch tweets from Twitter and broadcast them to the client in real-time.