To send an SMS in Python using Twilio, you need to have a Twilio account and a phone number with SMS capabilities. You also need to install the twilio library and create a script that uses your Twilio credentials to send a message to a verified phone number. The process involves creating a TwilioRestClient object using your account SID and authentication token, and then using this client to create a new message request to the Twilio API. Note that Twilio's free account has limitations on sending SMS messages to unverified numbers. Once you have set up your script, you can run it in Python and receive an SMS with a pre-defined body.