In a real-world application, .NET Core is used to build an ASP.NET Core 3.1 MVC application that integrates with Twilio products such as Twilio Studio, Twilio API for WhatsApp, and Twilio SendGrid. The application covers various aspects of building a real-world Twilio application, including serverless IVR and chatbot creation, database setup, code refactoring, email sending, and notification services. A detailed workshop covering these topics is available for free, aimed at making it easier for developers to implement these concepts into their own projects.