Twilio Pay aims to simplify the process of collecting digital payments securely for nonprofits and social enterprises. To build a donation system using Twilio Studio and Pay, one needs a free Twilio account, a configured payment connector such as Stripe, and access to a phone number where donors can call in to make donations. The process involves creating a Twilio Studio flow that captures credit card information, handles payments securely, and provides feedback to the donor. After setting up the payment connector and configuring the Twilio Studio flow, one must associate the correct flow with the phone number to trigger the donation system. Testing involves using a test phone and credit card to verify the functionality of the donation system. The guide aims to help nonprofits and social enterprises build a secure and efficient donations system using Twilio Pay.