Mobile browsers pose unique challenges for video communication web apps, including issues with camera and microphone access, audio handling, and browser support. To overcome these obstacles, developers should perform pre-call tests, notify participants when camera access is lost, ensure the microphone is working at all times, provide camera previews, and utilize best practices such as microphone and speaker checks. By following these guidelines, developers can deliver great video experiences in mobile browsers and avoid common pitfalls. The Twilio Video team has documented these best practices and provides updated code samples to help developers get started with implementing them.