The Open Sesame project uses Twilio Studio, Sync for IoT, and an ESP8266 dev board to control a garage door with voice commands. The flow starts with a greeting and collects user input using speech recognition, validates it, and dispatches instructions to the garage door actuator if correct. The system also includes error handling and provides feedback to users. To set up the project, users need to create a Twilio account, register their garage door device, and upload an ESP8266 firmware that connects to the network and device setup. The project demonstrates how to bridge human-to-human communication with machine-to-machine use cases using Twilio services and tools.