This guide provides a comprehensive overview of using Psycopg2, one of the most popular PostgreSQL adapters, to integrate PostgreSQL with Python code. It covers various aspects such as installation, connection management, query execution, and troubleshooting common errors. Additionally, it highlights the differences between Psycopg2 and SQLAlchemy, another popular adapter for Python applications. The guide also provides examples of using Psycopg2 in combination with TimescaleDB, a PostgreSQL extension that enhances performance for data-intensive applications dealing with time-series data.