To use the SingleStore MCP server with Claude, users must first install the Claude Desktop application on their desktop and set up a local SingleStore MCP server by cloning its GitHub repository and running the server source code. Once the server is set up, users can connect it to the Claude Desktop application by making settings changes in the application's configuration file. The connection requires an API key generated from the SingleStore Portal, which can be obtained by navigating to the "API Keys" menu item under the "Configuration" section. Users can also access database credentials if desired. With the server connected and configured, users can start using the SingleStore MCP server in a Claude chat to discover available tools and perform various tasks such as analyzing data.