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To build an Instagram client using Ruby, developers can follow this guide that covers signing up for the Instagram API, testing its endpoints, building a Sinatra app to interact with the API, and presenting data to users. The process involves choosing an API offering on RapidAPI, subscribing to it, and then using tools like curl or Insomnia to test its endpoints. A Sinatra app is built to fetch media information from the Instagram API, including comments, likes, and more, and present it to users in a user-friendly format. By leveraging this guide, developers can create their own Instagram client apps that provide valuable insights into social media data, such as image previews, comments, likes, and more.