To use the Instagram API with Python, you need to first ensure that Python is installed on your server, then get an API key from RapidAPI, subscribe to the Instagram API, and finally use the API with Python. The process involves creating an output template in Python, using the `http.client` library to connect to the Instagram API, and parsing the response data into a Python dictionary object. You can then create an HTML file that displays the Instagram posts in a grid format, and use this file as a widget or iframe on another site. The possibilities with the Instagram API are endless, including searching tags, incorporating photos on websites, viewing photos from specific locations in real-time, and more.