Prometheus and OpenTelemetry (OTel) are two open-source projects under the Cloud Native Computing Foundation that play crucial roles in observability, particularly in monitoring complex distributed systems. Prometheus is widely relied upon for monitoring and alerting within organizations, while OTel is a vendor-neutral open standard for instrumenting, generating, collecting, and exporting telemetry data. The OTel Collector supports Prometheus by ingesting metrics using the Prometheus receiver and other methods, such as the K8s cluster receiver and Kubelet stats receiver. Prometheus provides a time-series data store for storing metrics, whereas OTel focuses on instrumentation. The Target Allocator (TA) in the OTel Operator helps with scalability and fault tolerance in Prometheus monitoring by even distributing targets among a pool of OTel Collectors and discovering Prometheus custom resources. New Relic offers integrations with both Prometheus and Kubernetes, providing benefits such as more nuanced security and user management options, consolidating observability tooling, and executing queries to scale. Ultimately, the choice between using OTel or Prometheus depends on an organization's business needs.