Vercel's V0 has recently introduced integrations for Neon, Supabase, and Upstash, allowing users to add persistent storage and deploy full-stack applications in minutes. However, detailed prompting is crucial to guide V0 effectively. To illustrate this, the author created a time-clock application with a clear scope and incremental development, showcasing how well-defined prompts significantly enhance outcomes. The author emphasizes the importance of providing context, outlining project goals upfront, and guiding V0 through informed prompts to avoid misinterpretation. By doing so, users can rapidly prototype and deploy full-stack applications without unnecessary complexity. The integration with Neon Postgres is particularly useful for iterative development, offering a serverless experience that scales effortlessly with project needs. To set up Neon Postgres with V0, users follow the setup wizard and may need to adjust the generated code to meet their specific requirements. Effective issue handling involves reviewing and revising prompts to minimize scope creep and prevent unintended issues. By following these best practices, users can maximize productivity with V0 and Neon Postgres.