GraphQL is an API query language that represents data as a graph, allowing for efficient and flexible data fetching. GRANDstack is a full-stack framework that leverages GraphQL, React, Apollo, and Neo4j to build applications with a graph database. The framework provides auto-generated GraphQL CRUD APIs, takes into account the schema duplication issue, and optimizes queries using Cypher. This approach enables developers to create scalable and efficient GraphQL-based applications. GRANDstack is particularly useful for building internal tools and exposing externally-facing APIs. The framework's focus on developer productivity aligns with the popularity of previous stack solutions like LAMP and MEAN.