The Neo4j Query API is a production-grade HTTP API that enables Cypher interactions across all Aura tiers and cloud providers. It allows developers to query a Neo4j server via an HTTP API, providing an alternative to the officially supported drivers. The Query API can be used with R using the httr2 package, enabling the transformation of JSON responses into dataframes. A function called `neo4j_query` has been created to perform Cypher queries and return results as dataframes, which can then be used in various applications.