Oracle NetSuite offers a powerful API for integrating and extending business workflows. The evolution of its API offerings includes the transition from SOAP to REST, with the latter providing a simpler and more scalable way to access data. SuiteQL is an SQL-like syntax introduced alongside the REST API, allowing users to query data in a more efficient manner. However, both APIs have their pros and cons, with the SOAP API exceling in environments requiring limited transactions on standard objects and high security, while the REST API offers simplicity, flexibility, and speed. To set up API calls, users must create an integration record, assign roles and permissions, generate OAuth tokens, and use SuiteScript or SuiteQL to automate complex workflows. Deploying NetSuite APIs at scale requires careful consideration of performance, automation, and data layers, with tools like Nanonets providing a comprehensive solution for orchestrating these layers in harmony.