Matching multiple vendor bills to a single purchase order in NetSuite can be handled using the UI, API, or SuiteScript. The NetSuite UI allows for manual matching of POs with vendor bills, while the API and SuiteScript provide more automation options. However, integrating APIs requires significant effort and is recommended only for large-scale or complex integrations. A no-code solution like Nanonets provides a plug-and-play integration that automates vendor bill entry into NetSuite and sets up seamless 2-way PO matching in under 15 minutes, eliminating the hassle and confusion of manual processes.