Section 508 compliance is a set of legal guidelines that ensures individuals with impairments have access to electronic and information technology created, procured, maintained or used. It refers to Section 508 of the Rehabilitation Act, which aims to make digital content accessible to people with disabilities. To ensure website accessibility under Section 508 requirements, it's essential to align your site with WCAG 2.1 standards, focusing on perceivability, operability, understanding, and robustness. This involves providing alternative text for images, ensuring keyboard-only navigation, using semantic HTML tags, improving readability through color contrast and plain language, and including captions for multimedia content. Regular audits, updates, and user feedback are necessary to ensure compliance and deliver a seamless experience to all users.