Chrome's DNS cache can become outdated or corrupted, causing issues with website access. To clear the DNS cache in Chrome, open the `chrome://net-internals/#dns` page and click the "Clear host cache" button, which immediately clears the DNS cache for your browser. You should clear the DNS cache when websites are not loading, pages are not displaying correctly, error messages related to DNS appear, or you're unable to access certain websites. Clearing the DNS cache can help fix many common web browsing issues, but if issues persist, using a bug reporting extension like Jam can save time by creating comprehensive bug reports with detailed debug data and screen recordings.