The JAMStack (JavaScript, APIs, Markup) architecture is gaining popularity among developers for building fast-performing web applications. It combines the best of static and dynamic content by leveraging precompiled HTML files and client-side interactions. Key practices for using JAMStack in production at scale include utilizing CDNs for improved performance and user experience, proper caching settings to avoid stale or buggy pages, version control through Git, automated builds and deploys, atomic deploys for consistency, optimizing for Core Web Vitals, and considering headless CMS solutions.