The Esper Python SDK allows users to automate device tagging, group management, and other tasks using the Esper REST API. To start, users can retrieve device information using the "GET" endpoint and modify device tags using the "PATCH" endpoint. The Python SDK provides two functions for toggling a device into and out of Kiosk mode and changing a device alias. Users need to set up a configuration for the Esper client with their Enterprise ID, API Key, and Endpoint URL. The SDK also includes functions to wait for command responses and apply device-friendly names. By using the Esper Python SDK, users can automate tasks across multiple devices, making it easier to manage their fleet.