Datadog teams create on-call rotations to ensure continuous uptime for their critical services. The size of the team determines the structure of a rotation, balancing service coverage with sustainable workloads for responders. Each rotation's shift schedule aims to maximize effectiveness while considering well-being and productivity. Responders are trained and equipped with resources to handle on-call responsibilities, which separate from feature work to improve service reliability and velocity. The company provides comprehensive support, including training, backup responders, direct manager involvement, and tools like Datadog On-Call, to ensure the success of their on-call practice and team well-being.