Alert fatigue is a common problem in monitoring systems where an excessive number of alerts are generated or irrelevant alerts overwhelm teams, leading to a diminished ability to detect critical issues. To prevent and minimize alert fatigue, it's important to continuously review and update your monitoring strategy by identifying noisy alerts, taking preventive action to minimize future opportunities for alert fatigue, and using tools like Datadog to help manage and reduce the number of alerts. This can be achieved through tasks such as increasing evaluation windows, adding recovery thresholds, consolidating alerts with notification grouping, leveraging conditional variables, and scheduling downtimes.