This guide provides best practices for operating CockroachDB on Microsoft Azure, covering backups, compute and storage considerations, security, data locality, performance testing, and survivability goals. It emphasizes the importance of implementing an effective backup strategy, leveraging Azure's robust services to safeguard distributed data, and tailoring a strategy that meets organizational needs. The guide also discusses best practices for compute type, storage type, and network configurations, as well as security measures such as authentication and authorization, and compliance considerations. Additionally, it covers performance testing and survivability goals, including high availability configuration, replication constraints, and network configuration. By following these best practices, users can optimize their CockroachDB deployment on Azure for enterprise-scale workloads.