Aerospike application security best practices highlight the importance of authentication, password protection, and data encryption. Developers should use Aerospike authentication to isolate the impact of a credential leak, protect passwords with secret management solutions such as Hashicorp Vault or LDAP, and implement access control features to enforce the principle of least privilege. Additionally, encrypting data in transit using TLS is crucial, and mutual TLS (mTLS) may be required for certain security models. By following these best practices, developers can ensure that their Aerospike applications are secure and compliant with industry standards.