You can send SMS messages using NodeJS and Azure Functions by following these steps: First, create a new Azure Function project locally using the Azure CLI and Twilio library. Then, install the required packages, including Twilio, and configure your credentials in local.settings.json. Next, write the Azure Function code to use Twilio for sending SMS messages. Deploy the Azure Function to Azure using the Azure CLI or Cloud Shell. Finally, test the function by sending a POST request to its URL with query parameters for the message and number. With these steps, you can easily integrate Azure Functions with Twilio to send SMS messages using NodeJS in a scalable and cost-effective manner.